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KMID : 1134820190480030385
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 3 p.385 ~ p.389
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Protective Effects of Methanol Extract from Acanthopanacis cortex Shoots against Photoaging in Human Skin Fibroblast
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Lee Ha-Na
Hong Seong-Hwa
Heo Hui-Jin
Choe Hyeon-Jeong
Jeong Heon-Sang
Lee Jun-Soo
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Abstract
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Exposure to ultraviolet (UV) light can cause skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Ultraviolet exposure is also closely associated with down-regulation of collagen synthesis and up-regulation of matrix metalloproteinases (MMPs). In this study, we investigated the protective effects of methanol extract from Acanthopanacis cortex shoots (ACS) against UVB-induced photoaging in human skin fibroblasts (Hs68 cells). The ACS extract did not show any cytotoxicity at levels up to 50 μg/mL. The extract showed protective effects against UVB-induced (30 mJ/cm2) cell damage in a dose dependent manner. In addition, the extract significantly reduced UVB-induced generation of reactive oxygen species by 11, 18.2, and 31.6% at concentrations of 12.5, 25, and 50 μg/mL, respectively, when compared to UVB-irradiation alone. The extract prevented decreases in collagen levels by inhibiting the increases in MMP-1 and MMP-3 levels caused by exposure to UVB-irradiation in Hs68 cells. Taken together, these data indicate that methanol extract from ACS exerts anti-photoaging activities and therefore has the potential for use in cosmeceutical preparations.
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KEYWORD
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photoaging, fibroblast, collagen, Acanthopanax cortex shoots
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